The relation between in vitro disintegration time of sugar-coated tablets and physiological availability of sodium p-aminosalicylate

A study was carried out to relate in vitro disintegration time of coated tablets with physiological availability of sodium /»-aminosalicylate based on the urinary excretion of this drug by human subjects.It was found that tablets having in vitro disintegration times of longer than sixty-seven minutes were not completely available.Eight- hour urinary excretion of sodium /»-aminosalicylate gave the same general indication of availability as did the twenty-four- or thirty-two-hour collections and was equally precise.The results support earlier work based on the urinary excretion of riboflavin.The combined data suggest that the maximum time permitted for the in vitrodisintegration of coated tablets to ensure complete availability should be sixty minutes.