Discovery Of 5-Hydroxyalkyl-4-Phenylpyridines As A New Class Of Glucagon Receptor Antagonists
Bioorganic & medicinal chemistry letters(2002)
摘要
5-Hydroxyalkyl-4-phenylpyridines have been identified as a novel class of glucagon antagonists with potential utility for the treatment of diabetes. A lead structure with moderate activity was discovered through a high throughput screening assay. Structure-activity relationships led to the discovery of a potent antagonist, IC50=0.11 muM, more than 60-fold improvement over the lead structure. (C) 2002 Elsevier Science Ltd. All rights reserved.
更多查看译文
关键词
receptor antagonists,glucagon
AI 理解论文
溯源树
样例
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要