Symmetrical Derivatives Of C2-Substituted Pyrrolo[2,3-F]Quinolines: Synthesis, Cytotoxicity And Drug Delivery Studies

The synthesis, pharmacological properties and delivery characteristics in simulated aqueous gastric fluid of a series of symmetrical nitrogenated C2-substituted pyrrolo[2,3-f]quinolines are described. The cytotoxicity of the target molecules (5a-h) was evaluated in the human non-small lung cancer cell line NSCLC-N16-L16 in vitro. One compound (5e) showed sufficient activity (IC50 = 26.4 mu M) and satisfactory release characteristics from solid pharmaceutical formulations.