Verhinderung der Immunkomplex bedingten Zerstörung von Granulozyten durch Immunglobuline

Immunoglobulines block Fc-receptores on granulocytes both in vivo and in vitro. Damage and destruction of granulocytes through exposure to immune complexes can be pretended by pre-incubating the blood sample with intravenous immunoglobulines. Data on intravenous immunoglobulines and the digitalis-andidote BM (Fa b) demonstrate that the effect of intravenous immunoglobulines is localisated to the Fc-fragment of the immunoglobulines. In two patients with Kawasakisyndrome after intravenous immunoglobulines therapy the proportion of devitalised granulocytes was markedly decreased.