Synthesis of digalactosyl diacylglycerols and their structure-inhibitory activity on human lanosterol synthase.

Rie Tanaka,Yuichi Sakano,Akito Nagatsu,Masaaki Shibuya,Yutaka Ebizuka,Yukihiro Goda

Bioorganic & Medicinal Chemistry Letters（2005）

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摘要

Digalactosyl and monogalactocyl diacylglycerols, were synthesized. DGDG with two myristoyl groups at both sn-1 and sn-2 positions showed the most potent inhibitory activity on human lanosterol synthase.

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关键词

Colocasia esculenta,Glycolipid,Digalactosyl diacylglycerols,Lanosterol synthase,Cholesterol biosynthesis

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