Anti-inflammatory properties of rapamycin on leukocyte-endothelial cell interactions following profound hypoperfusion

Aims: We studied the translation inhibitor Rapamycin on its ability to modulate leukocyte-endothelial cell interactions following ischemia and reperfusion. During the inflammatory response, leukocyte rolling, adherence, and subsequent transmigration through the endothelial wall in the microcirculation are key steps in the inflammatory cascade and lead to further tissue injury.