Structure-Activity Relationships (Sar) Of Some Tetracyclic Heterocycles Related To The Immunosuppressive Agent Brequinar Sodium

William J Pitts,James W Jetter,Donald J Pinto,Michael J Orwat,Douglas G Batt,Susan R Sherk,Joseph J Petraitis,Irina C Jacobson,Robert A Copeland,Randine L Dowling,Bruce D Jaffee,Tracy L Gardner,Elizabeth A Jones,Ronald L Magolda

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS（1998）

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摘要

The structure-activity relationships of some tetracyclic heterocycles related to Brequinar were explored. Activities as inhibitors of dihydroorotate dehydrogenase and the mixed lymphocyte reaction are related to ring system, heteroatom placement, and pendant ring substitution. (C) 1998 The DuPont Merck Pharmaceutical Company. Published by Elsevier Science Ltd.

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关键词

tetracyclic heterocycles,structure-activity

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