Novel synthesis of o-naphthothiophenequinone derivatives via regioselective Diels–Alder reaction

A novel procedure to construct o-naphthothiophenequinones has been achieved from readily available o-benzothiophenquinones and N-dienes via Diels–Alder reaction-aromatization sequence as key steps. The absolute regioselectivity was established via Diels–Alder reaction of o-benzothiophenquinones with rich electron N-dienes.