Antibacterial activity of secondary metabolites of marine fungi ZJ27

The antibacterial activities of five compounds isolated from secondary metabolites of seaweed endophytic fungi ZJ27 were studied in Bacillus cereu,Bacillus subtilis,Escherichia coli,Staphylococcus albus,Sarcina luteus,and Staphylococcus aureus and the antifungal activities were tested in Aspergillus niger,Fusarium oxysporum,Rhizoctonia solani,and Candida albicans by the growth rate method.Different compounds had diffident antibacterial activities in the six bacteria.Compound 1 showed remarkable inhibition of B.subtilis,S.albus and S.luteus with an MIC of 0.1,0.2,and 0.2 μmol/mL,respectively.Compounds 1 and 2 had notable inhibition of A.niger,F.oxysporum,R.solani and C.albicans,with the IC50 values of compound 1 being 5.06,3.09,3.68,and 8.19 μmol/mL and those of compound 2 were 22.28,21.32,8.18,and 21.75 μmol/mL.As natural antibacterial substances,Compounds 1 and 2 have a great range of potential utilities and a prospect of development and are worth further study.