Poster 14: Evaluation of Novel Radiotracers Targeting Non-Dopaminergic Striatal Biomarkers in HD: 18F-FPEB and PET Imaging for Metabotropic Glutamate Receptor Type 5 (mGluR5) Expression in Healthy Subjects and Subjects with Huntington Disease (HD)

Conclusions 18 F-FPEB is a promising PET radiotracer for evaluating mGluR5 with excellent characteristics for human imaging. This first-in-human study indicates that 18 F-FPEB PET may detect early reductions in striatal and neocortical mGluR5 in relatively mildly symptomatic HD subjects. Future studies are ongoing to evaluate these objectives and other nondopaminergic striatal markers further.