Synthesis and biological evaluation of piperazinyl heterocyclic antagonists of the gonadotropin releasing hormone (GnRH) receptor

Bioorganic & Medicinal Chemistry Letters（2010）

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摘要

A series of bicycloheterocyclic replacements for the previously described benzimidazole template were prepared and tested for GnRH activity.

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关键词

GnRH,GnRH antagonist,Gonadotropin releasing hormone,Gonadotropin releasing hormone antagonist,GPCR

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