Spectrofluorometric investigations on the solvent effects on the photocyclization reaction of diclofenac

HELIYON(2023)

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Abstract
The solvent effects on the photochemical conversion rate of the photosensitizing drug diclofenac (DCF) were investigated using steady-state fluorescence spectroscopy. The spectral information obtained for the photochemical reaction of DCF in a set of neat solvents demonstrates that the photoconversion reaction rate of DCF is not only medium polarity dependent but also hydrogen -bonding dependent. The solvent effects were qualitatively and quantitatively assessed employing various solvatochromic models, including multi-parameter linear regression analysis (MLRA). Interestingly, the MLRA results (R = 0.99) revealed that the photoconversion rate increases with increasing solvent polarizability (pi*) and H-bond donor capability (alpha), whereas the rate decreases with increasing hydrogen-bond acceptor capability (beta). However, predominant effect of the solvent acidity compared to basicity and polarizability was observed. A hypothesis rationalizing the effects of H-bonding and medium polarity on DCF photoconversion reaction is presented and discussed.
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Key words
Diclofenac,Photoconversion,Fluorescence,Solvent effects,Solvatochromic models
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