Amplification and direct sequencing of a cDNA encoding human cytosolic 3-hydroxy-3-methylglutaryl-coenzyme A synthase
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression(1992)
Abstract
Cytosolic 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) synthase (E.C. 4.1.3.5) is a highly regulated enzyme involved in isoprenoid biosynthesis and therefore a potential target for cholesterol-lowering drugs. Up to now, primary structure data have only been available for chicken, rat and hamster HMG-CoA synthase. Using in vitro amplification and direct sequencing, we have determined the nucleotide sequence of the coding region of the human cytosolic 3-hydroxy-3-methylglutaryl CoA synthase cDNA.
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Key words
3-Hydroxy-3-methylglutaryl CoA (HMG-CoA) synthase cDNA,Cholesterol biosynthesis,Isoprenoid biosynthesis,(Human)
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