Early statin therapy restores endothelial function in children with familial hypercholesterolemia

Saskia de Jongh,Marc R Lilien,Jos op’t Roodt,Erik S.G Stroes,Henk D Bakker,John J.P Kastelein

Journal of the American College of Cardiology（2002）

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摘要

Conclusions Our data show significant improvement of endothelial dysfunction towards normal levels after short-term simvastatin therapy in children with FH. These results emphasize the relevance of statin therapy in patients with FH at an early stage, when the atherosclerotic process is still reversible.

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ALT,AST,BMI,CK,CVD,FH,FMD,HDL-C,LDL-C,TG,TC

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