Barrett食管上皮的微细结构及意义

Acta Academiae Medicinae Militaris Tertiae(2009)

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Abstract
目的通过透射电镜技术观察Barrett食管上皮的超微结构变化,并探讨其意义。方法内镜下诊断Barrett食管,在食管下段行内镜下黏膜活检,标本分别经福尔马林、戊二醛固定,对经内镜及病理证实为Barrett食管伴肠上皮化生的黏膜行透射电镜观察。结果Barrett食管上皮超微结构显示兼有鳞状上皮和腺上皮的结构特征,并多见一种形态特征介于黏液细胞和杯状细胞之间的"中间体"细胞。结论Barrett食管上皮超微结构提示Barrett上皮可能起源于食管的多能干细胞,并具有多向分化潜能。
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Key words
transmission electron microscopy,ultrastructure,Barrett’s oesophagus
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