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Adiposity and endometrial cancer: The stress of excess

K. Matsuo,S. Srivastava,P. Tripathi, L. Sonoda,E. Yoo,K. Pfaffenbac, L. Dubeau,A. Lee,Y. Lin

GYNECOLOGIC ONCOLOGY（2011）

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Abstract
Objective: Glucose-regulated protein (GRP) 78 is a critical component of the unfolded protein response that is activated in conditions of endoplasmic reticulum (ER) stress, such as obesity. Given the association of endometrial carcinoma with obesity, we hypothesize that higher levels of visceral adipocyte GRP78 in patients with endometrial carcinoma are associated with increased risk of recurrence.
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Key words
endometrial cancer,adiposity,stress
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