2018 correlation of 3-dimensional ultrasound computer-aided interpretation with dynamic contrast enhanced pelvic mri in the detection of post radical prostatectomy local recurrence of prostate cancer

You have accessJournal of UrologyImaging/Radiology: Uroradiology I1 Apr 20102018 CORRELATION OF 3-DIMENSIONAL ULTRASOUND COMPUTER-AIDED INTERPRETATION WITH DYNAMIC CONTRAST ENHANCED PELVIC MRI IN THE DETECTION OF POST RADICAL PROSTATECTOMY LOCAL RECURRENCE OF PROSTATE CANCER Mark Shimko, John Knoedler, and Lance Mynderse Mark ShimkoMark Shimko More articles by this author , John KnoedlerJohn Knoedler More articles by this author , and Lance MynderseLance Mynderse More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2010.02.2051AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Biochemical recurrence of prostate cancer (PAC) after definitive therapy with radical prostatectomy (RP) is known to occur in 25-30% of patients. Dynamic contrast enhanced (DCE) pelvic magnetic-resonance imaging (MRI) in conjunction with transrectal ultrasound-guided prostatic fossa biopsy (TRUSbx) is one method to diagnose such recurrences. Novel, 3-dimensional ultrasound (3-D u/s) tissue differentiation analysis (HistoScanningTM - HS) may further characterize structures indiscernible to standard u/s scans and potentially aid in precise biopsy targeting. METHODS Nine consecutive men with increasing prostate-specific antigen (PSA) following RP and detectable masses on pelvic DCE MRI, underwent 3-D u/s of the prostate fossa in conjunction with ultrasound-guided biopsy The mean pre-biopsy PSA was 2.27 ng/mL and all had gadolinium-enhancing masses at the urethrovesical anastomosis or bladder neck. With IRB approval and after real time TRUSbx, the 3-D u/s data set was analyzed using HS software. RESULTS Five of the nine men had biopsy-proven local recurrence of their PAC at the site of the DCE MRI abnormality. All five of these men had detectable signal in the region of DCE MRI abnormality on HS analysis ranging from 0.03 to 1.91 cm3 in size. One of the four men with a negative biopsy had detectable HS signal volume of 0.57 cm3. CONCLUSIONS Computer-aided interpretation of 3-D u/s (HS) correlates highly with DCE MRI abnormalities and recurrent PAC detected by TURSbx. This technology by may improve the detection of PAC local recurrence following RP and allow more precise guidance of biopsies as well as salvage therapy targeting. Rochester, MN© 2010 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 183Issue 4SApril 2010Page: e783 Advertisement Copyright & Permissions© 2010 by American Urological Association Education and Research, Inc.MetricsAuthor Information Mark Shimko More articles by this author John Knoedler More articles by this author Lance Mynderse More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...