Prioritizing Migraine Biomarkers Research
DRUG DEVELOPMENT RESEARCH(2007)
Abstract
Migraine is among the most common chronic disorders in the developed countries, affecting up to 17% of adult women and 6% of adult men. It is also among the chronic disorders most commonly associated with recurring absence from work. It has been estimated that in the United States the indirect annual societal cost of migraine, mostly as lost work, is US$12 billion. Migraine diagnosis and treatment is hindered by the lack of reliable serum or genetic biomarkers that could potentially improve treatment choices. Research programs focused on identifying and developing migraine biomarkers for both prevention and treatment must be included in the national biomedical research agenda.
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Key words
migraine biomarkers, direct costs, indirect costs, plasma calcitonin gene-related peptide (CGRP), tumor necrosis factor-alpha (TNF-alpha), angiotensin-converting enzyme, National Institute of Neurological Disorders and Stroke
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