Analogs of MK-499 are differentially affected by a mutation in the S6 domain of the hERG K+ channel.

Jerzy Karczewski,Jixin Wang,Stefanie A Kane,Laszlo Kiss,Kenneth S Koblan,J Christopher Culberson,Robert H Spencer

Biochemical Pharmacology（2009）

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摘要

Mutation of the S6 pore residue F656A in the hERGchannel dramatically reduces the potency of MK-499 but does not reduce the potency of the ketoneanalog L-702,958.

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关键词

AAS,HERG,hERG,Kv,LQTS,CHO

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