Glucose-6-Phosphate Dehydrogenase Deficiency Diagnosed in an Adolescent with Type 1 Diabetes Mellitus and Hemoglobin A1c Discordant with Blood Glucose Measurements

Disorders of hemolysis reduce the exposure time of hemoglobin to glucose, resulting in a falsely low hemoglobin A1c level. This case report describes the unexpected diagnosis of glucose-6-phosphate dehydrogenase deficiency made during evaluation of discordant HbA1c and blood glucose measurements. (J Pediatr 2011; 158: 849-51)