Research on Excretion and Distribution of Toxic Heavy Metals of Seventy-flavor Pearl Pill in Beagle Dogs

Objective To study the distribution and excretion of heavy metals in dogs aftergiven Seventy-flavor Pearl Pill for a long time.Methods Seventy-flavor Pearl Pills were given orally to Beagle dogs at a dose of 1 g/kg.The concentration of toxic heavy metals in blood,excrement and urine were compared with those in control group 12 weeks after drug administration and 4 weeks after drug withdrawal.Results The concentration of to toxic heavy metals increased in blood,excrement and urine when the was drug given and decreased in blood during drug withdrawal.The toxic heavy metals were accumulated in the heart,liver and kidney and eliminated when drug administration was suspended.Conclusion The risk of accumulation of toxic heavy metals deserves attention when Seventy-flavor Pearl Pills are used at a heavy dose for a long time.