Estimation of metabolite concentrations of healthy mouse brain by magnetic resonance spectroscopy at 7 T

In vivo 1H short echo-time magnetic resonance spectra exhibit overlapping spectral components from many metabolites. Metabolite concentrations are obtained by quantitating such spectra. Quantitation is difficult due to the overlap of metabolite resonances, macromolecules and lipids and to the presence of the water residue. Moreover, the signals have low signal-to-noise ratio. A fitting algorithm invoking extensive prior knowledge is needed. We quantitated 1H in vivo mouse brain signals obtained at 7 T using the time-domain algorithm QUEST combined with an in vitro metabolite basis set. Brain metabolite concentrations estimated from eight mouse brain signals are compared to previously reported results. To cite this article: C. Cudalbu et al., C. R. Chimie 9 (2006).