延髓头端腹内侧核群的GABAA受体部分介导丙泊酚在中脑导水管周围灰质腹外侧区诱发的痛觉过敏作用
Suzhou University Journal of Medical Science(2010)
Abstract
目的 观察丙泊酚在中脑导水管周围灰质腹外侧区(vlPAG)诱发的痛觉过敏是否通过延髓头端腹内侧核群(RVM)的GABAA受体介导.方法 采用热板法和福尔马林试验,将大鼠随机分组,丙泊酚和倚包牡丹碱分别采用vlPAG和RVM置管及微量注射给药.分别以舔后爪潜伏时间和疼痛评分为痛阈指标.结果 两种疼痛模型中丙泊酚在vlPAG微量注射后(丙泊酚组)均引起痛觉过敏(P<0.01),预先在RVM注射荷苞牡丹碱(丙泊酚+荷包牡丹碱组)可部分拈抗这种作用.结论 丙泊酚在vlPAG引起痛觉过敏,这种作用部分是通过RVM的GABA.受体中继而发挥作用的.
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Key words
formalin test,hot plate test,bicuculline,propofol,GABAA receptor,ventrolateral portion of the periaqueductal gray,hyperalgesia,rostral ventromedial medulla
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