EP01.07: Clinical relevance of angiogenic factors in late onset pre‐eclampsia

The clinical significance of sFlT1:PlGF ratio in late onset pre-eclampsia is unclear. The aim of the present study was to evaluate the relationships of this parameter with maternal and perinatal outcomes. This is a pilot prospective case-control study. In total 45 pregnant women, 16 with late onset pre-eclampsia (> 34 weeks) (8 mild and 8 severe) and 29 controls were studied. sFlT1, PlGF and ratio sFlT1:PlGF ratio was measured by immunoassay (Roche Corp). Patients were classified in mild and severe pre-eclampsia. Relationships with hematological, biochemical, Doppler parameters and perinatal outcomes were studied. Student t test, ANOVA test and Pearson's coefficient correlation were used. Statistical significance was set at 95% level (p <0.05). sFlt1 and sFlT1:PlGF ratio were significantly increased and PlGF was decreased in women with late onset pre-eclampsia in comparison to controls. Overlapping was more pronounced for PlGF than for both sFLt1 and sFlT1:PlGF ratio. There were no significant differences between mild and severe cases in the level of angiogenic factors. However, sFlT1:PlGF ratio was significantly correlated with creatinine, ALT and AST (r = 0.53, p = 0.03, r = 0.54, p = 0.03, r = 0.58, p = 0.01 respectively). In the subgroup of women with pre-eclampsia sFlT1:PlGF ratio was significantly correlated with uterine artery PI (r = 0.82, p = 0.005) and both PlGF and sFlT1:PlGf were corrlelated with birthweight in centiles (r = 0.59, p = 0.02 and r = - 0.65; p = 0.01). In women with late onset pre-eclampsia angiogenic factors may identify women with defective placentation but their relationships with maternal morbidity although present is poor. EP01.07: Table 1. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.