Mechanism of Manganese Neurotoxicity

Mn mainly enters the body by inhalation,but organic Mn enters the body by skin absorbing,and growing evidence suggests that nasal deposition and transport along olfactory neurons represents another route by which inhaled Mn is delivered to certain regions of brain.Mn neurotoxicity mainly shows manifestations in nerve system.The early manifestations mainly are neurasthenic syndrome,and it shows extracorticospinal tract disorders in advanced stage.Mechanism of Mn neurotoxicity is not elucidate clearly.Academicians have been studying on disorders of neurotransmitter,dysfunction synaptic conduction,injury of free radical,apoptosis and gene polymorphism.