An unusual patient with hypothyroidism, tophaceous gout, and marked joint destruction.
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS(2008)
摘要
This report describes a 75-year-old Caucasian man with extensive urate deposits and severe gouty arthropathy that confined him to a wheelchair. Since age 50, he suffered multiple acute gout flares and progressive deformities in his hands, feet, knees, and elbows (tophi). Serum creatinine was 1.4 mg/dL and serum urate 9.4 mg/dL. Conditions known to increase uric acid production (psoriasis, chronic bronchitis) and to decrease uric acid excretion (hypothyroidism, metabolic syndrome, and nephroangiosclerosis) may operate in a single patient, illustrating the dramatic clinical course of untreated gout.
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关键词
uric acid,hyperuricemia,tophus,gout,hypothyroidism
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