Solubility measurement of methyl anthranilate in supercritical carbon dioxide using dynamic and static equilibrium systems

The solubility of methyl anthranilate in supercritical carbon dioxide was determined using dynamic and static equilibrium systems. Three temperatures (40, 60 and 80 degrees C) and a pressure range between 160 and 340 atm were applied for the dynamic solubility measurements. The flow rate was maintained at 0.5 mL min(-1) in the dynamic solubility measurements, where the solute solubility was claimed to be independent of the flow-rate factor. Two temperatures (40 and 60 degrees C) and the pressure range between 100 and 265 atm were used in the static equilibrium system. The crossover pressure region was observed between 220 and 240 atm in the static system, but was not seen in the dynamic system. The solubility of methyl anthranilate determined by the static system was consistently higher than the dynamic solubility measurement, indicating that the static technique provided more reliable solubility data for methyl anthranilate than the dynamic technique. The solubility data obtained with the static system were in good agreement with the predictive models based on the Chrastil equation and the Peng-Robinson equation of state with the Panagiotopoulos and Reid mixing rule. (c) 2006 Society of Chemical Industry.