Deletion/insertion polymorphism in the angiotension - converting enzyme gene as a risk factor in the Slovenian patients with coronary heart disease
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY(2000)
摘要
. The angiotensin-converting enzyme (ACE) plays by degradation of angiotensin I and bradykinin, an important role in modulations of smooth muscle proliferation and vascular tone. Typical plasma levels of ACE accompany the I/D polymorphism; however, a controversy exists as to whether the DD genotype of the ACE polymorphism affects the risk for the development of coronary heart disease (CHD). We compared the I/D polymorphism in 171 Slovenian CHD patients that were younger man 55 years with 134 healthy control individuals. The DD genotype is associated with a 2.3 - fold increase in the risk for CHD.
更多查看译文
关键词
Key words: angiotensin-converting enzyme,genetic polymorphism,risk factor,coronary heart disease
AI 理解论文
溯源树
样例
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要