A gene-environment interaction between HLA SE alleles and smoking affects the reactivity of ACPA to various citrullinated antigens
ANNALS OF THE RHEUMATIC DISEASES（2010）
Abstract
It has recently been postulated that a specific interaction exists between genotype, smoking and autoimmunity to citrullinated α-enolase peptide (CEP-1), and that therefore, the major genetic and environmental susceptibility factors for RA are mainly associated with the development of anti-CEP1-positive disease. It is unclear however, if this interaction is truly …
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Key words
gene environment interaction
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