Reaction of erythromycin with dissolved oxygen on gold nanoparticle-modified glassy carbon electrodes

Cyclic voltammetry was used to investigate the reaction of erythromycin (EM) with dissolved oxygen on gold nanoparticle-modified electrodes prepared via electrodeposition. A well-defined reduction peak at −0.420 V and a reoxidation peak at −0.055 V were observed. With the addition of EM into the NaOH solution containing dissolved oxygen, the oxidation peak at −0.055 V was still indiscernible. However, a new oxidation peak at 0.200 V appeared, which suggests the interaction between EM and dissolved oxygen. Therefore, this method can be used for the analysis of EM in tablets. The present method is simple, reproducible, and does not require complex analytical instruments.