Experimental study on influence of Shenfu Injection on carcinemia of mice bearing Lewis lung cancer

Objective: To observe the effect of Shenfu Injection on carcinemia and study its mechanism.Methods: Mice C57 Lewis lung cancer model were established.The changes of physiological conditions(body weight,food and water intake),the serum levels of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6) and interleukin-1(IL-1) were observed in the experiment.Results: Shenfu Injection can signifi cantly increase water and food intake of carcinemia mice,and inhibited the loss of body weigh(P0.05).Levels of TNF-α,IL-1 and IL-6 decreased in Shenfu Injection group obviously(P0.05).There was no signifi cant difference between Shenfu Injection group and Medroxyprogesterone(MPA) group.Conclusion:Shenfu Injection had remarkly effect on carcinemia,which may depend on decreasing TNF-α,IL-1 and IL-6.The further mechanism should be explored by the next study.