Synthesis and collateral dilator activity of nitroxyalkylamides having direct or latent sulfhydryl moieties.

Bioorganic & Medicinal Chemistry Letters(2003)

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摘要
To develop an orally active, long-acting nitrate that does not induce tolerance, nitroxyalkyl compounds were prepared and their activities evaluated by the use of carotid collaterals in anesthetized dogs. A compound having a favorable pharmacological profile, that is, long-lasting collateral vasodilatation and little hypotension, and lack of nitrate tolerance, was chosen for further evaluation.
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关键词
nitroxyalkylamides,collateral dilator activity,latent sulfhydryl moieties,synthesis
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