Ribofuranose as a carrier of tetraoxane and 4-aminoquinoline antimalarial pharmacophores
JOURNAL OF THE SERBIAN CHEMICAL SOCIETY(2008)
摘要
Several tetraoxane and 4-aminoquinoline molecules were prepared in order to examine the influence of ribofuranose as a carrier molecule on the antimalarial activity of test compounds. The synthesized compounds showed pronounced antimalarial activity against Plasmodium falciparum chloroquine susceptible D6, chloroquine resistant W2 and multidrug-resistant TM91C235 (Thailand) strains. The aminoquinoline derivative 4 was more active against W2 and TM91C235 strains than the control compounds (CQ and MFQ).
更多查看译文
关键词
tetraoxanes,4-aminoquinolines,malaria,P. falciparum
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要