Discovery and SAR of hydrazide antagonists of the pituitary adenylate cyclase-activating polypeptide (PACAP) receptor type 1 (PAC1-R).

Xenia Beebe,Daria Darczak,Rachel A Davis-Taber,Marie E Uchic,Victoria E Scott,Michael F Jarvis,Andrew O Stewart

Bioorganic & Medicinal Chemistry Letters（2008）

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摘要

Potent small molecule antagonists for the PAC1-R have been discovered. Previously known antagonists for the PAC1-R were slightly truncated peptide ligands. The hydrazides reported here are the first small molecule antagonists ever reported for this class B GPCR.

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关键词

PACAP,Class B GPCR,PAC1-R,Hydrazides

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