Lack of replication in polymorphisms reported to be associated with atrial fibrillation

Moritz F. Sinner,Steven A. Lubitz,Arne Pfeufer,Seiko Makino,Britt-Maria Beckmann,Kathryn L. Lunetta,Gerhard Steinbeck,Siegfried Perz,Rosanna Rahman,Akshata Sonni,Steven M. Greenberg,Karen L. Furie,H.-Erich Wichmann,Thomas Meitinger,Annette Peters,Emelia J. Benjamin,Jonathan Rosand,Patrick T. Ellinor,Stefan Kääb

Heart Rhythm（2011）

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摘要

Conclusion Our results suggest that previously reported associations to AF were likely false positives and highlight the need for systematic replication of genetic associations in large, independent cohorts to accurately detect variants associated with disease.

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关键词

Atrial fibrillation,Arrhythmia,Genetics,Single nucleotide polymorphism,Replication,Meta-analysis

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