Myeloproliferative Disorders Terminating in Acute Micromegakaryoblastic Leukaemia

Summary. Two cases of myeloproliferative disorder—one of myelofibrosis with agnogenic myeloid metaplasia and one of chronic granulocytic leukaemia terminating in acute micromegakaryoblastic leukaemia—are presented. The clinical course is described, and results are reported of morphological, cytometric, cytochemical and cytogenetic studies, as well as cell culture of blood cells in soft agar and in fluid medium.