CPT-11联合5-Fu/FA方案治疗34例晚期结直肠癌的疗效观察
Journal of Basic and Clinical Oncology(2007)
Abstract
目的评价CPT-11联合5-Fu/FA方案治疗晚期结直肠癌的临床疗效及毒副反应。方法全组34例,可评价疗效31例,其中3周方案14例,2周方案17例。3周方案:CPT-11 270 mg/m2静滴,d1,FA 200 mg/m2静滴,d1-5,5-Fu 425 mg/m2静滴,d1-5,21 d为1个周期,2个周期(6周)评价疗效;2周方案:CPT-11 180mg/m2静滴,d1,FA 200 mg/m2静滴,d1-2,5-Fu 400 mg/m2静推,随后5-Fu 600 mg/m2静滴22 h,d1-2,14 d为1个周期,3个周期(6周)评价疗效。结果CR 1例,PR 11例,SD 14例,PD 5例,总缓解率38.7%,总稳定率45.2%。中位缓解时间7.1个月,中位稳定时间8个月。主要毒副反应为迟发性腹泻(Ⅲ/Ⅳ度发生率为32.4%)及中性粒细胞减少(Ⅲ/Ⅳ度发生率为35.3%)。结论CPT-11联合5-Fu/FA两种方案治疗晚期结直肠癌有效率高,毒副反应可以耐受,可作为晚期结直肠癌的一线或二线化疗方案。
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Key words
clinical efficacy,irinotecan(CPT-11),colorectal cancer,chemotherapy
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