Effect of protein kinase C inhibitor (PKCI) on radiation sensitivity and c-fos transcription
International Journal of Radiation Oncology*Biology*Physics(2001)
Abstract
Purpose: The human genetic disorder ataxia-telangiectasia (AT) is a multisystem disease characterized by extreme radiosensitivity. Although ionizing radiation was known to induce c-fos transcription and cellular protein kinase C (PKC) induces the expression of this immediate response gene, little is known about how mutated AT (ATM) or PKC-mediated signal transduction pathway modulates the c-fos gene transcription and gene expression. Here we have studied the effect of PKC inhibitor (PKCI) on radiation sensitivity and c-fos transcription in normal and AT cells, and also studied whether PKCI effect on c-fos occurs in Ras-dependent pathway.
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Key words
Radiation sensitivity,Ataxia-Telangiectasia,PKCI,c-fos
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