结肠清颗粒对溃疡性结肠炎模型大鼠血清IL-1、ICAM-1含量的影响
China Modern Medicine（2009）
Abstract
目的:探讨结肠清颗粒对溃疡性结肠炎模型大鼠血清白细胞介素1(IL-1)、细胞黏附因子(ICAM-1)的影响.方法:用家兔结肠加弗氏佐剂复制大鼠溃疡性结肠炎模型,检测模型大鼠血清IL-1、ICAM-1含量.结果:结肠清颗粒能显著增加溃疡性结肠炎模型大鼠血清IL-1及ICAM-1的含量:显著降低溃疡性结肠炎模型大鼠结肠的病理改变,对模型大鼠结肠有显著的修复作用.结论:结肠清颗粒治疗溃疡性结肠炎的作用可能与其升高血清IL-1及I-CAM-1的含量,从而改善免疫功能,减轻炎症损伤有关.
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Key words
Jiangchangqing,IL-1,Ulcerative colitis,ICAM-1
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