Discovery and structure–activity relationship of a novel spirocarbamate series of NPY Y5 antagonists

Colin P. Leslie,Jonathan Bentley,Matteo Biagetti,Stefania Contini,Romano Di Fabio,Daniele Donati,Thorsten Genski,Sebastien Guery,Angelica Mazzali,Giancarlo Merlo,Domenica A. Pizzi,Fabiola Sacco,Catia Seri,Michela Tessari,Laura Zonzini,Laura Caberlotto

Bioorganic & Medicinal Chemistry Letters（2010）

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摘要

The synthesis and SAR of a series of potent NPY Y5 antagonists is reported. Optimization led to the identification of compounds 23p and 23u (fpKi=10.0).

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NPY Y5

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