牛膝正丁醇萃取物对小鼠繁殖性能的影响
Journal of Northwest Sci-Tech University of Agriculture and Forestry(Natural Science Edition)（2006）
Abstract
用不同剂量(0.5,2.0,4.0 g/kg)牛膝正丁醇萃取物给配对前的成年小鼠连续灌喂15 d,检测部分雄鼠精液品质、睾丸发育情况和内脏器官;同时在雌、雄小鼠合笼后观察小鼠妊娠及胚胎发育情况,以探讨牛膝正丁醇萃取物对成年小鼠繁殖性能的影响.结果表明,牛膝正丁醇萃取物不能明显干扰小鼠的繁殖性能,小鼠可以正常发情、妊娠,且胎儿发育正常,仅4.0 g/kg剂量处理组母鼠的胎仔数与其他各组相比差异显著(P<0.05).2和4 g/kg灌喂剂量可引起小鼠脾脏、肝脏、肾脏出现急性炎症反应.
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Key words
viscera,mice,n-butanol extract from Achyranthes bidentata,reproductive performance
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