孕妇外周血中胎儿DNA及瘦素含量与子痫前期发病的关系
Acta Academiae Medicinae Qingdao Universitatis(2007)
Abstract
目的探讨孕妇外周血中胎儿DNA及瘦素含量与子痫前期发病的关系。方法选择30例子痫前期孕妇为子痫前期组(其中轻度18例,重度12例),B超确定所妊娠的胎儿为男性,于孕20周前、发病时、分娩后6 h抽取外周血;另选30例正常孕妇为对照组,B超确定所妊娠的胎儿为男性,对应子痫前期组时间取血液标本。采用荧光定量PCR及放射免疫方法检测孕妇外周血胎儿DNA浓度及瘦素水平。结果孕20周及发病时胎儿DNA浓度,轻度子痫前期较对照组明显升高,重度子痫前期较轻度者明显升高(F=84.80、96.79,q=11.37~17.30,P<0.05);分娩后6 h胎儿DNA浓度,子痫前期组较对照组明显升高(t′=18.65,P<0.05)。子痫前期发病时瘦素值,轻度子痫前期较对照组明显升高,重度子痫前期较轻度子痫前期明显升高(F=26.46,q=19.23、21.24,P<0.05)。子痫前期病人血液中胎儿DNA与瘦素水平呈正相关关系(r=0.997,P<0.05)。结论孕妇外周血胎儿DNA及瘦素水平与子痫前期发病具有相关性。
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Key words
leptin,DNA,eclampsia
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