Synthesis And Structure-Activity Relationship Of C-3 Benzoyloxymethyl Cephalosporins Exhibiting Anti-Mrsa Activities
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS（1997）
Abstract
A series of cephalosporins bearing C-3 benzoyloxymethyl groups were prepared and evaluated for their anti-MRSA activity and plasma stability. They exhibit excellent in vitro activity (MIC = 0.06 similar to 2 mu g/mL) against MRSA and excellent stability in human plasma. (C) 1997 Elsevier Science Ltd.
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Key words
structure activity relationship
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