Tumor cell growth suppression by tannic acid.

Tannic acid was cultured together with tumor cells that had originated from om human malignant tumors (HCT-15 & AGS). Significant suppression of tumor growth was observed ed. The 50% suppression was observed at the concentration between 50 mu g/ml and 12.5 mu g/ml. When tannic acid was injected into HCT-15 cells by electroporation at 1180 mu p and 200 Omega the suppression rate was 34.3% at the concentration of 50 mu g/ml in HBS solution. The suppression rate of cells only in contact with tannic acid solution for one hour under the same conditions as used for electroporation, was 26.1%. Histographic findings suggested that tannic acid almost completely blocked the S phase of the cell cycle.