Study on the β_2AR polymorphism in asthmatic abnormal black savda patients

Objective: To search the features of β2-adrenergic receptor (β2AR) gene polymorphism. To investigate the relationship between β2AR gene and the abnormal black savda in asthmatic patients. Methods: Divided the patients into four body fluids according to Uighur medicine theory. The β2AR gene polymorphism of thirty abnormal black savda asthmatic patients 46 cases of other asthmatic patients and 89 cases of normal control groups was testedly PCR-SSP. Results: Among 30 cases of asthmatic abnormal savda patients, 28 cases have already expressed serious asthmatic conditions (93.3%), the genotype of 16 position mutation homozygote occupied 63.9% (P0.01), the arginite homozygote occupied 7%, glycin/arginine heterozygote occupied 30%. There is no significant changes on β2AR polymorphism of gene at position 27 (P0.05). Conclusion: There is a high risk of abnormal black savda in developing serious asthma, maybe there is an association between mutation of arginine to glycin on position 16.