Design of bivalent ligands using hydrogen bond linkers: synthesis and evaluation of inhibitors for human β-tryptase
Cheminform（2004）
Abstract
Alternative to a covalent linker, hydrogen bonds can be used to link ligands for maintaining simultaneous interactions with multiple binding sites. This is exemplified by the synthesis and evaluation of amide derivatives as potent inhibitors of human β-tryptase.
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Key words
Hydrogen bonds,Tryptase,Enzyme inhibitors,Structure-based design
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