Antibodies To Recombinant Human Tissue Transglutaminase Levels Are Related With Histological Lesions

Aim. In coeliac disease (CD) children the small bowel lesions can be patchily distributed or present only on the bulb mucosa (JPGN, 2004). Anti-tissue transglutaminase autoantibody (tTGAb) assay is a useful tool in selecting candidates undergoing intestinal biopsy. Serum tTGAb detected with the novel fluid-phase radioimmunoprecipitation (RIA) method proved to be the most sensitive test (Am J Gastroenterol, 2001; JPGN, 2006). The aim of this study was to investigate whether tTGAb levels are related to histological lesions.