An Efficient Access To The Enantiomers Of Alpha-Methyl-4-Carboxyphenylglycine Via A Hydantoin Route Using A Practical Variant Of Preferential Crystallization As3pc (Auto Seeded Programmed Polythermic Preferential Crystallization)

The enantiomers are obtained in preparative amounts without a resolving agent via the following sequence: hydantoin synthesis, resolution by entrainment, and ring cleavage by means of hydrolysis in basic conditions. The new variant of preferential crystallization (AS3PC), implemented without using seeds, shows good reproducibility and yield. (C) 1997 Elsevier Science Ltd.