Impact of omega-3 fatty acids supplementation in acute lung injury patients: a Meta-analysis of randomized controlled trials

Objective: To evaluate the impact of omega-3 fatty acids intervention on clinical outcomes in acute lung injury patients.Methods: Literatures relating to the evaluation of the omega-3 fatty acids in acute lung injury patients were searched in databases including PubMed,EMBASE,Cochrane Library,Web of Science,Chinese Biomedical Databases,China National Knowledge Infrastructure,and Wanfang Database etc.All the eligible studies were randomized controlled trials and their results were published up to October 2012.The quality of the included studies was evaluated by Jadad evaluation standard.The data were analyzed with RevMan 5.1 from the Cochrane Collaboration.Results: Totally 6 randomized controlled trials entered final meta analysis study and the baseline data of each trial were comparable.The results showed a significant effectiveness in the PaO2,PaO2/FiO2,Total Protein,LOS.However,the length of LOV stay and adverse effects showed no significant difference between two group.Conclusion: Omega-3 fatty acids interventions can benefit patients by reducing the morbidity of postoperative infectious complications and shortening the length of hospital stay.