Cytotoxicity and structure–activity relationships of four α-N-heterocyclic thiosemicarbazone derivatives crystal structure of 2-acetylpyrazine thiosemicarbazone
Bioorganic & Medicinal Chemistry Letters(2009)
Abstract
Four α-N-heterocyclic thiosemicarbazone derivatives were synthesized and tested for in vitro cytotoxicity against K562 leucocythemia cell line and BEL7402 liver cancer cell line, respectively. Different substituents on the thiosemicarbazone ligands show different levels of antitumor activity.
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Key words
Thiosemicarbazone,Crystal structure,Cytotoxic activity
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